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KMID : 0361020010440101023
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Korean Journal of Otolaryngology - Head and Neck Surgery
2001 Volume.44 No. 10 p.1023 ~ p.1027
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The Effects of IL-1β in Cerebrospinal Fluid on Hearing in the Guinea Pigs
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이정구/Chung Ku Rhee
장용주/박근환/오장근/박우성/오충훈/Yong Ju Jang/Keun Hwan Park/Jang Keun Oh/Woo Sung Park/Chung Hun Oh
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Abstract
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Background and Objectives : Cytokines such as interleukin-1β(IL-1β) released into cerebrospinal fluid (CSF) during bacterial meningitis play an important role in causing inflammation and tissue damage. Bacterial meningitis is often complicated
by
a
sensorineural hearing loss. The present study is to investigate the effect of IL-1β injected into CSF on hearing in guinea pigs. Materials and Methods : Thirty guinea pigs (60 ears) were randomly assigned to the following three groups ; 1)
Control
group receiving intracisternal PBS injection. 2) 10 ng group receiving intracisternal injection of 10 ng/ml of IL-1β. 3) 100 ng group receiving intracisternal injection of 100 ng/ml of IL-1β. Auditory brainstem response (ABR) was performed
before
the
injection, 10, and 24 hours after the injection of PBS and IL-1β. The concentration of IL-1βin the perilymph was measured in each group. Result : The ABR threshold shift at 10 and 24 hours were respectively 3.3±2.6 dB, 2.8±2.0 dB in the
control
group, 21.94±14.46 dB, 5.83±9.74 dB in the 10 ng group, and 21.58±15.99 dB, 4.74±9.05 dB in the 100 ng group. The ABR thresholds were significantly increased in the 10 and 100 ng groups compared to the control group at 10 hours, but they were
not
significantly different at 24 hours after the injection. The concentrations of IL-1β in the perilymph at 10 hours were 2.17±0.6 ng/ml in the 10 ng group and 3.58±1.1 ng/ m in the 100 ng group. Those were 0.53±0.1 ng/ml in the 10 ng and
0.86±0.2
ng/ml in the 100 ng groups at 24 hours after the injection. Conclusion : The results of this study showed that IL-1β released into CSF during meningitis may play an important role in causing hearing loss.
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